Day 2 :
Biography:
Prerna Kohli is a clinical psychologist who believes in the practice of holistic mental health to treat her patients. She has been awarded the 100 women Achievers Award by the Honorable President of India, Sheri Pranab Mukherjee. Kohli offers heart-based workshops and lectures on preserving balance in life, creating selfawareness, and developing inner peace. Kohli blends intuitive wisdom with 21 years of experience to create a powerful holistic approach while specializing in the area of emotional change. She holds a Ph.D. in clinical psychology that she received at Aligarh Muslim University, Aligarh, India. Kohli has used her degree not only in her private practice but also to help guide multinational companies to create happy and productive work environments.Kohli loves to dedicate her time to help eradicate social issues. She has worked with NGOs such as Nav Jyoti, Khushii, Amar Jyoti and is currently a member of the Vishaka committees against women's sexual harassment in organizations such as Press Bureauo f Information. She has also been working with Tihar Jail inmates in to teach them life skills and is a member of their POSH committee. A mother of two, Kohli believes that a necessary trait is compassion and tries to inculcate this trait not only in her children bualso her patients. As she believes compassion helps alleviate emotional pain from both the givers and receivers life. In April 2017, Kohli was the Director of Scientiï¬ c Sessions for the World Health Global Action Summit held under the aegis of the WHO. The theme was Depression
Abstract:
Depression is the epidemic of the century. Across the world the statistics are alarming. In India the statistics are distressing: A student commits suicide every hour in India Every 3 seconds there is an attempted suicide in India 22.4% of the Indian population above the age of 18 years in age suff er from substance use disorder Over 56.7 million people in India suff er from Depression, approximately the population of the United Kingdom Only 0.06% of the healthcare budget in India is spent on Mental Healthcare Th ere is a severe shortage of specialists in India, there are only 4000 psychiatrists, 3500 psychologists, and 3500 mental health social workers While 150 million Indians need mental health care, only 30 million are seeking care
- Depression | Mental Disorder | Narcissistic Personality Disorder
Location: Carlton Palace Hotel | Dubai
Chair
Ernesto Mangiapane
IPSA, Italy
Session Introduction
Neha Kulkarni
Leeds University, UK
Title: The role of individual differences and age groups in depression
Time : 11:15-11:45
Biography:
Abstract:
Biography:
Ernesto Mangiapane is a clinical psychologist with a psychoanalytic orientation, EMDR (Eye Movement Desensitization and Reprocessing) therapist, expert in intervention techniques in psycho-legal and criminological contexts, master degree in Criminology and Forensic Psychopathology, Professional Certificate in Forensic Psychology, expert in Persecution Sciences, Membership in APA
- American Psychological Association, Society for Clinical Neuropsychology, Trauma Psychology, Membership British Psychological Society, Membership ESRII (European Society for Research on Internet Interventions), ANFOS (National Association of Workplace Safety Trainers) trainer, Scientific technical consultant at “Armando Curcio” Institute. He has been a research and teaching assistant for the chair of Developmental Psychopathology at the University of Palermo. Currently he is the President of the association “Orizzonti Onlus”, and President of “Kairos A.C.F.P.” (Association for Criminal and Forensic Psychology). Last publications: Mangiapane, E. (2018). Stalking: theoretical, technical and methodological aspects. In Mangiapane, E., & Amodio, S. (EDS.),
Abstract:
Post-Partum Depression (PPD) is defined as depression with the onset of symptoms during pregnancy or within 6 weeks of delivery. The PPD occurs in 10- 15% of the new mothers and if not diagnosed it is present in 50% at 6 months, and in 25% at a year (Trop et al., 2018) . The implementation of a protocol is essential to examine the current diagnostic criteria, the probability of performing differential diagnosis or to find predictors of risk factors for PPD. Screening tools must be able to establish the right timing of action and women acceptability. The support path arises from the collaboration between those who provide primary care to women - Midwives and Ob/Gyn and mental health professionals - Psychologists and Psychiatrists (Missonnier S., 2003). The selected professional figures are called on a longitudinal management of the cases, in order to ensure a holistic treatment and a close follow-up. The multidisciplinary aspect of treatment for PDD reflects the need for health of every woman and her child and has positive implications for the family and the whole society. If no action is taken, the PPD is a significant risk factor for the development of the child as well as for the style of insecure attachment to the caregiver (Coyle et al., 2000). It has been documented how the risk of depression affects maternal behavior, limiting emotional expression and the quality of relational exchanges, within the process of mutual emotional regulation (Ammaniti et al., 2006). PPD can lead to an affective dysregulation and a deficit in psycho-biological synchronization which represents a psychopathological vulnerability for the child. Psychoneuroimmunology studies on PPD show how the main risk factor is related to the inflammatory process increased by stress (it increases the level of cortisol - a hormone often elevated in depressed people) . Normally inflammation increases during the last trimester of pregnancy - a period when there is also a high risk of depression (Kendall-Tackett KA. A, 2007). The use of the multidisciplinary protocol would lead to the prevention of psychopathological disorders in the child.
Biography:
CEO and Clinical Psychologist at the clinic ‘The Listener’. Head of psychology department at Talk to me, Pakistan’s first helpline. Certified CBT therapist by Pakistan Association of Cognitive Therapists . Member of Pakistan Association of Clinical Psychologists. Member of American Psychological Association. Executive member of Chamber of Commerce and Industry Bahawalpur Pakistan. Member of Pakistan association of Cognitive therapists. Member of Global Research and Development Services. Visiting faculty at numerous universities.
Abstract:
With the growth of social media and its popularity spreading amongst all spheres of life including business ,family life, social interactions, dealings , education and relationships, it is causing daunting challenges relating to the mental health for young adults. This lifestyle change is making them more vulnerable to negative thought processes including social comparisons, isolation and mental in capabilities all leading to depression. The scale of this social issue has been accepted and recognized even by the biggest tech entrepreneurs of current times .This is ironic because inventions from these tech entrepreneurs have been the major factors behind the growth of social media globally.
It is therefore the need of the hour to further probe this important area that how social media is causing depression amongst young adults.
Milan Kumar
Amity Neuro Care and Epilepsy Clinic, India
Title: ECT in depression ( Indian Perspective)
Biography:
Dr. Milan Sojitra has completed his graduation in MBBS at the age of 22 years from Bhavnagar University and post graduation in Psychiatry from Same institute. He was also a fellow of neurology in a wellknown institute name as shree satya sai institute of higher medical sciences, bangalore and certified in stroke management.He is the director of Amity Neuro Hospital. He has special interest in epilepsy, stroke and electrophysiology.
Abstract:
In depression, the identification of predictors of fast response is necessary to improve patient selection for ECT. In a double-blind, prospective study of 320 endogenously depressed patients treated with ECT, we attempted to identify the clinical characteristics of ECT responders which predicted fast (requiring ≤ 5 treatments to produce maximum recovery) and slow (requiring ≥ 6 treatments to produce maximum recovery) response to ECT. Of the 220 ECT responders in the study, 130were fast and 90were slow responders. We found that male sex, and greater age associated with lesser initial severity of depression were significantly associated with fast recovery. Surprisingly, factors suggested or expected to predict good outcome with ECT failed to predict fast outcome. Finally, the treatment variables of mean seizure duration and stimulus waveform were found to be unrelated to recovery rate. The findings are briefly discussed.
Biography:
My name is Laura Maria Brenner Ceia Ramos Mariano da Rocha and I was born and raised in
the South of Brazil.
Graduated in Medicine at the Pontifical Catholic University of Rio Grande do Sul, PUCRS, Brazil
in 1983.
From 1983 to 1987 I worked in the USA as a fellow researcher in the field of Diabetic
Neuropathies at the University of Miami Jackson Memorial Hospital, Miami, Florida.
In 2010 I obtained my Masters Degree in Biomedical Gerontology (CAPES Concept 7) at the
Pontifical Catholic University of Rio Grande do Sul, PUCRS, Brazil.
Title: Translation and Cultural Adaptation of the Aging Perceptions Questionnaire (APQ) for the
Portuguese Language.
In 2014 I obtained my PhD in Biomedical Gerontology (CAPES Concept 7). at the Pontifical
Catholic University of Rio Grande do Sul, PUCRS, Brazil.
Title: Auto perception of Aging, Self - Esteem, Auto image and Prevalent Morbidities in Elderly,
For both my Masters degree and my PhD I had a scholarship from the Coordination for the
Improvement of Higher Education Personnel, CAPES, Brazil.
In 2018 I obtained my Specialization Degree in Psychiatry - Title: Omega Three and
Schizophrenia / a literature review at the Abuchaim Institute, Brazil.
I am currently taking a Post-Graduation Course in Analytic Psychotherapy at the
Federal University of Rio Grande do Sul, UFRGS, Brazil.
I am a member of the ISNPR - International Society for Nutritional Psychiatry Research.
I am a member of the Brazilian Psychiatric Association and the Psychiatric Association of Rio
Grande do Sul. I am currently a professor at Abuchaim Institute at the Specialization Course in Psychiatry.Nutrition and Mental Health, Depression and Morbidities in the Elderly
Abstract:
In our current society, there is a demand that people be, or appear to be, independent and autonomous, individualistic and, consequently, have difficulty establishing affective bonds, since interpersonal relationships as well as products and services are given the label of disposable . At the same time, body worship, self-image, increased demands on physical appearance, diminish frustration tolerance and the ability to deal with limits, making people more and more isolated and into themselves. Contributing to this scenario, we also have the invasion of privacy, sensationalism and banalization of feelings, highlighting the emptiness and lack of references, so characteristic of narcissism. Narcissism is rarely the reason one appears for medical help. Depression offers an insight into this balancing act between perceived greatness and proclaimed depravity
Biography:
Prabha K Raman, is a CDA licensed psychologist holding a Masters’ Degree in Psychology and PG Diploma in psychotherapy and counseling. She is also a certified psychometrician, NLP master practitioner, certified wellness coach, and have an Advanced Diploma in Hypnosis. She have been in the UAE for the past 17 years, currently working as a school counselor in Raffles World Academy. She have been working in various schools as a psychology teacher and elementary, middle and senior school counselor in the past. Her passion has always been to work with young children.
Abstract:
Most people experience a range of positive and negative emotions in a day or in a span of several days. When someone starts experiencing negative feelings such as sadness, tearfulness, emptiness or hopelessness more often and if these feelings become extreme and unpleasant, they are important signals that something is wrong. But they’re only symptoms of an unconscious cause. For instance, feeling depressed is often an indication that the person may have internal image of a dreary future, or maybe there’s a low, slow, internal voice saying, “It’s miserable.” What helps a person to come out of this feeling is being cared for and supported.
It comes easily for us to show compassion to a person who is going through above emotions. However when it comes to ourselves, we often start self-blame and criticizing our thoughts and actions. Often people look for this support in the external world. The most vital support can be provided by believing in ourselves and being empathetic to ourselves. This would be possible through accepting that you are not the only one with problems and giving self-affirmations. All these are means of being self-compassionate.
Through this workshop we will have an overview about self-compassion and also look in to one of the NLP techniques that would train us to be self-compassionate. The one hour workshop aims to help you at both personal and professional level. By practicing self-compassion, we will learn to consider our problems in the light of human experience and subsequently help us in accepting our weaknesses and imperfections. This gives us more open mindedness and we can be in a better position to propagate awareness of self-compassion to our clients.
Biography:
Moses Chung (20 years of teaching experience) completed his Masters Degree in Psychology
at the age of 42 from the DoualaUniversity and being registered for phd in Psychology in the
same university. A holder of a Second Cycle Teacher Trainer Diploma from the University
of Bamenda, Cameroon, member of the IACCP ( International Association For Cross
Cultural Psychology), CPA( Cameroon Psychological Association) He is the Divisional
Adviser of Pedagogy for Upper Plateaux Division in Cameroon. A consultant for the
SOCIETY FOR PROMOTION OF INITIATIVES IN SUSTAINABLE DEVELOPMENT
AND WELFARE. He has published two articles in reputed journals in his country.
Abstract:
This study was carried out to investigate the impact of behavioural ambivalences of
both maternal and paternal parent communities during and after inter-communal conflicts on
mixed anxiety- depressive disorders in young adults of bi-communal families.
The problem is that young adults of bi-cultural parents are prohibited from going to
war against their maternal community yet members of both communities still reject these
young adults, treating them with love and hate.
This study employed the Double Bind Theory. Two hypotheses set for the study
were:(H1;) Protection-rejection behavior of paternal community and :(H2) Protection-
rejection behaviour of the maternal community during and after inter-communal conflicts
determines anxiety- depressive disorders among young adults born of inter-communal
families.
A sample of 10 Oku, 10 Mbessa, 10 mixed Oku-Mbessa and 10 mixed Mbessa-Oku
young adults were selected. After passing the HADS test, 03 mixed participants with highest
scores were given clinical interviews.
From the scores on the thematic content analysis, results showed that the three
participants were victims of ambivalent behaviours (6/6, 5/6, 5/6 respectively) and positive
for mixed anxiety-depression disorder (5/9, 7/9, 7/9 respectively). This suggests that
ambivalent behaviours of parent communities during the conflicts influenced mixed anxiety-
depression disorder among young adults of mixed families.
Therefore with cultures and traditions as major triggers, conflicting demands from
children of bi-cultures during war can provoke mixed anxiety-depression.
Keywords: Ambivalence. Bi-Communal Families. Mixed Anxiety- Depressive Disorders
Neha Kulkarni
Leeds University, UK
Title: The role of Individual Differences and age groups in Depression
Biography:
In my research on Generations at workplace, it was discovered that Generation X (The generation born 1965-1981) experiences low well being at work. I found that it was linked to work life balance. One good reason for this could be attributed to the fact that this generation has the burden of responsibility of their old parents and teenage children. A healthy work life balance is also responsible for an overall feeling of well-being.
The Millennials generation,however, had a good work life balance which was responsible for well-being.
Abstract:
Happiness appears to be the end of every goal. The area of happiness and well-being have been a trending topic of research in the recent past. Certain personality traits can increase the risk of depression.
When it comes to the Big 5 Ocean Model, personality characteristics such as Neuroticism (with traits such as emotional instability, self-consciousness and negative thought process) has predicted depression.In some of the studies, it was reported that Neuroticism is the strongest correlate for psychopathology. Whereas, conscientiousness (with traits such as self discipline, persistence and organization) has been associated with lower levels of depression as conscientious people proactively avoid pitfalls in life. Lower level of conscientiousness has been associated with lower life satisfaction, risk taking behaviour, drug addiction and high level of depression. Although there has been no consistent evidence suggesting any association with extraversion, it has been seen in many literature, that a combination of high levels of neuroticism, low extraversion and low conscientiousness has been a predictor of Depression in the long run. These combined traits have also been a subject of discussion in terms of treatment resistance by patients.
Biography:
Abstract:
Post-Partum Depression (PPD) is defi ned as depression with the onset of symptoms during pregnancy or within 6 weeks of delivery. Th e PPD occurs in 10-15% of the new mothers and if not diagnosed it is present in 50% at 6 months, and in 25% at a year (Trop et al., 2018). Th e implementation of a protocol is essential to examine the current diagnostic criteria, the probability of performing diff erential diagnosis or to fi nd predictors of risk factors for PPD. Screening tools must be able to establish the right timing of action and women acceptability. Th e support path arises from the collaboration between those who provide primary care to women - Midwives and Ob/Gyn and mental health professionals - Psychologists and Psychiatrists (Meissonier S., 2003). Th e selected professional fi gures are called on a longitudinal management of the cases, in order to ensure a holistic treatment and a close follow-up. Th e multidisciplinary aspect of treatment for PDD refl ects the need for health of every woman and her child and has positive implications for the family and the whole society. If no action is taken, the PPD is a signifi cant risk factor for the development of the child as well as for the style of insecure attachment to the caregiver (Coyle et al., 2000). It has been documented how the risk of depression aff ects maternal behavior, limiting emotional expression and the quality of relational exchanges, within the process of mutual emotional regulation (Amanita et al., 2006). PPD can lead to an aff ective deregulation and a defi cit in psycho-biological synchronization which represents a psychopathological vulnerability for the child. Psychoneuroimmunology studies on PPD show how the main risk factor is related to the infl ammatory process increased by stress (it increases the level of cortisol - a hormone oft en elevated in depressed people). Normally infl ammation increases during the last trimester of pregnancy - a period when there is also a high risk of depression (Kendall-Tackett KA. A, 2007). Th e use of the multidisciplinary protocol would lead to the prevention of psychopathological disorders in the child
Biography:
Abstract:
Milan Sojitra Maharaja Krishnakumarsinhji
Amity Neuro Care and Epilepsy Clinic, India
Title: Clinical prediction of rate of response of endogenous depression to electroconvulsive therapy
Biography:
Milan Sojitra has completed his graduation in MBBS at the age of 22 years from Bhavnagar University and post graduation in Psychiatry from Same institute. He was also a fellow of neurology in a wellknown institute name as shree satya sai institute of higher medical sciences, bangalore and certiï¬ ed in stroke management. He is the director of Amity Neuro Hospital. He has special interest in epilepsy, stroke and electrophysiology.
Abstract:
In depression, the identifi cation of predictors of fast response is necessary to improve patient selection for ECT. In a doubleblind, prospective study of 320 endogenously depressed patients treated with ECT, we attempted to identify the clinical characteristics of ECT responders which predicted fast (requiring ≤ 5 treatments to produce maximum recovery) and slow (requiring ≥ 6 treatments to produce maximum recovery) response to ECT. Of the 220 ECT responders in the study, 130were fast and 90were slow responders. We found that male sex, and greater age associated with lesser initial severity of depression were signifi cantly associated with fast recovery. Surprisingly, factors suggested or expected to predict good outcome with ECT failed to predict fast outcome. Finally, the treatment variables of mean seizure duration and stimulus waveform were found to be unrelated to recovery rate. Th e fi ndings are briefl y discusseda
Biography:
My name is Laura Maria Brenner Ceia Ramos Mariano da Rocha and I was born and raised in the South of Brazil. Graduated in Medicine at the Pontiï¬ cal Catholic University of Rio Grande do Sul, PUCRS, Brazilin 1983.From 1983 to 1987 I worked in the USA as a fellow researcher in the ï¬ eld of DiabeticNeuropathies at the University of Miami Jackson Memorial Hospital, Miami, Florida.In 2010 I obtained my Masters Degree in Biomedical Gerontology (CAPES Concept 7) at thePontiï¬ cal Catholic University of Rio Grande do Sul, PUCRS, Brazil
Abstract:
In our current society, there is a demand that people be, or appear to be, independent and autonomous, individualistic and, consequently, have diffi culty establishing aff ective bonds, since interpersonal relationships as well as products and services are given the label of disposable. At the same time, body worship, self-image, increased demands on physical appearance, diminish frustration tolerance and the ability to deal with limits, making people more and more isolated and into themselves. Contributing to this scenario, we also have the invasion of privacy, sensationalism and banalization of feelings, highlighting the emptiness and lack of references, so characteristic of narcissism. Narcissism is rarely the reason one appears for medical help. Depression off ers an insight into this balancing act between perceived greatness and proclaimed depravity
Prabha Krishnakumar Raman
Raffles World Academy, UAE
Title: Self-compassion- Key to a healthier happier you
Biography:
Abstract:
- Depression| Mental Ilness| Stress Manegement
Chair
Joel Gailledreau
Mini International Neuro Psychiatric, France
Session Introduction
Zahra Hussain Alshabeeb
Al Amal Complex for Mental Health-Dammam, Saudi Arabia
Title: Counseling Patients on Antidepressant Medications
Time : 11:00-12:00
Biography:
11 years experience as Drug information and Medication Safety Officer, pharmacist with Bachelor of clinical Pharmacy from King Saud University, Riyadh- Saudi Arabia Supervisor in 397 hotline for medication consultation (MOH National Drug Information Call Center) Chairman of Drug Information Committee , Pharmaceutical Care Eastern Health- Saudi Arabia Editor in Chef of East Pharmacist Bulletin Certified Professional Healthcare Trainer by the American Institute of Professional Studies -29 Jan 2017-2nd Feb 2017 Certified Professional Healthcare Trainer by by Inspire Institute Certified Professional Healthcare Trainer by by Leaders of care training and Development Certified Trainer of The Trainers by International Motivation Training Center Member & coordinator of Pharmacy & Therapeutics Committee in Al Amal complex for mentalhealth- Dammam Member of medication safety Committee in Al Amal complex for mental health- Dammam Contributed with lectures in many psychiatric conferences and events.
Abstract:
Improving Adherence to Antidepressants and other psychotropic medications Identify the key counseling points for patients receiving Antidepressants Discuss protocol of Patient counseling clinic Service in MOH Hospital Pharmacy in Saudi Arabia
Biography:
Moses Chung (20 years of teaching experience) completed his Masters Degree in Psychology at the age of 42 from the DoualaUniversity and being registered for phd in Psychology in the same university. A holder of a Second Cycle Teacher Trainer Diploma from the University of Bamenda, Cameroon, member of the IACCP ( International Association For Cross Cultural Psychology), CPA( Cameroon Psychological Association) He is the Divisional Adviser of Pedagogy for Upper Plateaux Division in Cameroon. He has published two articles in reputed journals in his country.
Abstract:
This study was carried out to investigate the impact of behavioral ambivalences of both maternal and paternal parent communities during and aft er inter-communal confl icts on mixed anxiety- depressive disorders in young adults of bicommunal families. Th e problem is that young adults of bi-cultural parents are prohibited from going to war against their maternal community yet members of both communities still reject these young adults, treating them with love and hate. Th is study employed the Double Bind Th eory. Two hypotheses set for the study were:(H1;) Protection-rejection behavior of paternal community and :(H2) Protection-rejection behavior of the maternal community during and aft er inter-communal confl icts determines anxiety- depressive disorders among young adults born of inter-communal families. A sample of 10 Oku, 10 Mesa, 10 mixed Oku-mesas’ and 10 mixed mesas’-Oku young adults were selected. Aft er passing the HADS test, 03 mixed participants with highest scores were given clinical interviews. From the scores on the thematic content analysis, results showed that the three participants were victims of ambivalent behaviors (6/6, 5/6, 5/6 respectively) and positive for mixed anxiety-depression disorder (5/9, 7/9, 7/9 respectively). Th is suggests that ambivalent behaviors of parent communities during the confl icts infl uenced mixed anxiety-depression disorder among young adults of mixed families. Th erefore with cultures and traditions as major triggers, confl icting demands from children of bi-cultures during war can provoke mixed anxiety-depression.
Rahila Qazi
Meridian Health Services, USA
Title: Religion and mental health: A discussion of how religion impacts mental health/Bio-Psycho-Social mode of treatment
Biography:
Abstract:
The poster presentation is based on a research of how religion impacts mental health. Th e positive and negative eff ects of belief on emotional well-being. Th e purpose is to share my research report and to open up a discussion of how people view religion when it comes to their emotional health. Th e idea is to shift the way neuropsychiatric illnesses like depression and anxiety are Perceived and treated from strictly analyzing chemicals to a more holistic approach that looks at person's unique genetic makeup and life style. In the past 25 years, we have learned a tremendous Amount about the mechanisms in the brain that regulate emotional behavior. We can track the eff ects of diff erent medicines on the brain and then their short comings when it comes to patients who Are treatment resistant. As science continues to advance, America's biopharmaceutical companies are working to develop medicines these diseases into manageable conditions. Researchers are studying biomarkers and the ways current medicines impact the pathology of the brain. Despite that progress, far too mny people still suff er with mental illness in silence, while too many other seek treatment only to fi nd insuffi cient remedies. It is time to think outside the box to bring the balance back in life
Shu-yi Sophie Chen
Polytechnic University, Hong Kong
Title: The structure activity relationship of antidepressants and the specificity in drug therapy
Biography:
Shu-yi Sophie Chen is the ï¬ nal year student in the Department of Applied Biology and Chemistry Technology at the Hong Kong Polytechnic University in Hong Kong. She had been a visitor student in the Department of Life Sciences at the Peking University in Beijing, China in 2017. Shu-yi Sophie Chen had received the Talents Development scholarship by the Hong Kong S.A.R. government in 2017 and Reaching Out Award in 2016 for her medical volunteer placement in Sri Lanka by the Hong Kong S.A.R. government respectively. She had been exploring the medicinal chemistry in pharmacological therapy in antidepressants research as her ï¬ nal year project under the guided by Dr Ga-Lai LAW at the Hong Kong Polytechnic University. Shu-yi Sophie Chen had also completed a medical placement and volunteer works in the Paediatric Surgery Units in the Karapitiya Teaching Hospital in Sri Lanka in 2016.
Abstract:
Antidepressants are prescribed commonly in depression therapy in the pharmaceutical methods; however, the long term administration time which is approximately 10 to 20 days and the unpleasant side eff ects are still accompanied during the medication therapy. Consequently, the full profi le of the medicinal chemistry of the antidepressants is discussed for an ideal structure in drug affi nity. Antidepressants can be divided into diff erent types that depend on diff erent neurotransmitters as a target to serve as reuptake inhibitors. Furthermore, antidepressants can be categorized into (SSRIs) selective serotonin reuptake inhibitors and (SNRIs) selective norepinephrine selective reuptake inhibitors. Th e structure activity relationship of antidepressants is the goal in this project to explore the full profi le of specifi c structure in binding affi nity and specifi city. A better view of the structure in antidepressants is benefi cial to establish a highly potent and precise antidepressant design. Halogens are found common in the antidepressants compound for the purpose of drug affi nity. Especially, the fl uorine atom will serve as hydrogen bond acceptors that contribute to a high affi nity in protein-ligand interaction, particularly in association with O-H or N-H group in the binding protein. Both the fl uoxetine and paroxetine contains fl uorine as the substituted group. However, the position matters when it comes to the affi nity that the substituted group in fl uoxetine occupy only 4’-position while paroxetine occupies both 4’- and 3’-position on the aryloxy ring that proposes the spatial confi guration of the substitution group is signifi cant. Furthermore, the fl uoxetine contains trifl uoromethyl group on the phenolic rings in the Para-position exhibit 6-fold potency in SSRI activity compared to its parent non-fl uorinated structure. In summary, a more clear direction in the development of antidepressants can be suggested to be related to both the types and positions of substituents on the aromatic rings. Mostly, these antidepressants are not only treated to depression disorder but also can be used in other health condition such as NRIs in chronic pains and ADHD. Hence, an outcome of improved effi cacy in terms of its specifi city and potency of antidepressants can benefi t people to overcome the healthy condition and provide a more profi le in the drug design